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Microdosing Magic Mushrooms for Anxiety and Depression

Micro-Dosing is the practice of regularly using small amounts of a psychedelic substance to test or benefit from its physiological effects without the undesirable bodily and cognitive side effects.


Read on to discover how micro-dosing psilocybin containing mushrooms can improve your cognitive function and alleviate symptoms of depression and anxiety.

Micro-Dosing and Psychedelic Medicine

Natural psychedelic substances have been used for their beneficial health effects for thousands of years. These psychedelics include psilocybin extracted from magic mushrooms, DMT from Ayahuasca, and mescaline from Peyote.


There is a lot of interest in using low doses of psychedelic drugs as part of a treatment plan for helping people suffering from depression, anxiety, and post-traumatic stress disorder. Psilocybin has also been shown clinically to help with the treatment of depression, anxiety, and treating addictions such as smoking and drug abuse.



These medical studies have used regular doses of psilocybin which produce hallucinogenic and euphoric effects, but these doses of psilocybin may also generate uncomfortable or frightening ‘bad trip’ experiences. This has led to the adoption of a practice called micro-dosing. This is the consumption of small amounts of a psychedelic substance to benefit from the healing effects without the distracting and scary hallucinogenic effects.


When your micro dose psilocybin it should not impair your cognitive or bodily function. This means that you can live a normal daily life whilst taking a very small amount of a psychedelic on a regular basis. Many people who micro dose psilocybin, or any other psychedelic, will use about 10% of the regular dose of psilocybin for 2 to 5 times a week. This low dose is about 100 to 300 milligrams of dried magic mushrooms.

Micro-Dosing and Your Mental Health

An increasing amount of research suggests that there are many positive benefits of micro dosing for mental health and cognition. Scientific studies indicate that people who micro dose psilocybin display an improved mood and a reduction.in the symptoms of stress, anxiety, and depression over a one-month period.  This suggests that micro dosing psilocybin, the main psychoactive ingredient in magic mushrooms, helps to reduce or negate anxiety and depression symptoms as well as improving your overall cognitive ability.



Several medical research teams have conducted medical studies on anxiety and depression. They have importantly observed improvements in mental health patients from micro dosing psilocybin to their overall mood and mental health conditions. For those experiencing concerns with their mental health, improvements were observed and one of the studies has found out that psilocybin micro dosing helps patients to have happier moods and improved mental health.

Challenges of Psilocybin Psychedelic Research

Observational studies and individual healing experiences indicate that micro-dosing psilocybin or other psychedelics enhances your mood, improves your cognitive function, and reduces the symptoms of depression and anxiety. Most of the medical studies have been done under strict rules because all psychedelics have been made illegal by most governments including the UK and most of Europe. So only a few studies have been conducted that compare the longer-term effects of micro-dosing psilocybin with a control group over a longer time.



There are many obstacles to conducting experiments with psychedelics to ascertain the true healing effects of hallucinogenic substances.  Many participants in previous studies which used placebos in a control group were able to recognize the effects of the psilocybin onset and trip during the study, even if the effects were mild. So, these volunteers are aware of the psychedelic drug which will introduce a significant amount of statistical bias. Also, study volunteers will expect positive effects to their health and healing that are due to the use of psilocybin. This can also increase positive results in placebos as the brain may mimic the effects of the onset of psilocybin, especially if the volunteer has taken magic mushrooms before.


Scientists want to know the full potential health benefits of micro-dosing. To do this a more natural approach needs to be undertaken. To do this, researchers would track changes in mental health and mood of volunteers who were already taking micro doses of psilocybin. Then it is easier to compare mood changes, changes in their mental health and cognitive function over time. Typically, a period of one month is monitored and compared with people who have not taken any psilocybin, and who are sober from other substances.

Micro-Dosing Psilocybin with Lion’s Mane Mushrooms and Niacin

In some medical studies, micro-dosing psilocybin was combined with other substances such as the Lion’s Mane mushroom. Lion’s Mane is has well observed therapeutic effects for reducing the symptoms of mild cognitive impairment and depression. Also, vitamin B3, also known as niacin, improves absorption of Lion’s Mane mushrooms and psilocybin. Niacin can possibly enhance the effects of both types of mushrooms.



Volunteers who micro-dosed magic mushrooms displayed improved mood and reduced symptoms of depression, anxiety, and stress. This was significantly higher than those who had not micro-dosed psilocybin.  The positive effects of micro-dosing were observed in all participants. This includes those that used psilocybin alone, psilocybin with Lion’s mane mushrooms, and psilocybin with lion’s mane mushrooms and niacin.


Across different genders and age groups including people who had or had no mental health issues, it was found that micro-dosing psilocybin had a similar level of improvement in their mental health and mood. Older people who micro-dosed using a combination of psilocybin, lion’s mane, and niacin, showed greater improvements in some of the tests but without any clear increase in cognitive function. The only other exception were women who showed a greater reduction in the symptoms of depression than men.

Micro-dosing Magic Mushrooms Is Good for You

The results are promising from science regarding the healing potential of psilocybin. With more clinical trials and increased sample sizes, it is likely that medical science will confirm that psychedelics, including magic mushrooms, are of value for health, healing, brain cognition, and well-being. The effects are similar for all people tested with some variations for women and people over 55. It would be great if the experiments can be conducted with larger groups of people to increase the sample sizes used.



It is unclear as to the degree of the benefits of micro-dosing magic mushrooms and there is great benefit from taking a large dosage of psilocybin at least once under supervision. The modest improvements observed in the clinical trials may be due to expectation of positive results or it may be pharmacological in nature. Certainly, comparing trials with people who micro-dose with those who take large doses of psychedelics, including psilocybin, LSD, mescaline, and DMT, will reveal more about the healing and cognitive benefits of psychedelics in general.



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