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The Healing Potential of Magic Mushrooms in the Battle Against COVID-19

With all the hype about the therapeutic healing properties of psilocybin mushrooms, it is no surprise that magic mushrooms are being tested as a possible remedy for the ongoing COVID-19 pandemic. Continue reading to discover how therapeutic mushrooms and their magical chemical compounds are being used in the fight against the coronavirus.

The Science Behind Magic Mushrooms and COVID-19

The historical use of psychedelic mushrooms by ancient cultures and civilisations dates back to over 2300 years. Historical figures like Hippocrates, the father of Western medicine, recognized the potential healing properties of many species of mushrooms. Also, the famous discovery of penicillin also owes its origins to fungi, highlighting the legitimate role of mushrooms in medicine.


Recently, medical researchers have unearthed various metabolites associated with therapeutic mushrooms, each boasting remarkable antibacterial, antiviral, and anticancer properties. There are thousands of mushroom species worldwide and psilocybin mushrooms may hold the key to treating COVID-19. Psilocybin containing magic mushrooms possess receptors that bind onto human cells that bind specific mushroom components, facilitating the regulation of immune cell behaviour. This mechanism offers potential in combating the coronavirus.

In fact, psychedelic mushrooms contain many psychedelic compounds including psilacetin, psilocin, and psilocybine, which may inhibit the spread of the key viral component known as SARS-CoV-2 Mprotease. These compounds exhibit significant binding capabilities to Mprotease. This suggests that psilocybin-containing mushrooms may be potent chemotherapeutic agents against SARS-CoV-2 thus offering a potential avenue for the treatment of COVID-19 infections.

Ongoing Medical Trials

From November 20921, early-stage trials have commenced that investigate the use of medicinal mushrooms and Chinese herbs in the treatment of mild to moderate COVID-19 cases. These trials, including ones at UCLA and the University of California San Diego, are designed to assess the effectiveness of these treatments in quarantined patients with mild to moderate symptoms.


A groundbreaking FDA-approved clinical trial, conducted by top researchers at the University of California, is studying the use of natural medicine, including medicinal mushrooms and Chinese herbs, to fight COVID-19. This study aims to test the safety, feasibility, and efficacy of a modified herbal formula in conjunction with medicinal mushrooms in a multi-centre, double-blind, randomized placebo-controlled trial.

The mushroom varieties that are being examined and tested in these trials are Turkey Tail and Agarikon. In each trial, researchers aim to recruit 66 individuals in quarantine with mild to moderate COVID-19 symptoms. Participants will be randomly assigned to receive either the mushroom combination, Chinese herbs, or a placebo over a two-week period.


The trial is also focussing on establishing the safety of the herbal formula, including traditionally effective but controversial herbs and magic mushrooms. The study is developing simpler ways of dosing the modified herbal formula such as in a convenient capsule. Researchers are dedicated to overcoming the challenges in botanical drug development to provide new therapeutic avenues for COVID-19 treatment.

Magic Mushroom Medicine and Immune Response

Originally concerns were raised about the use of magic mushrooms to treat active coronavirus infections because of the possible of increasing cytokine storms, a severe complication of COVID-19. However, experts suggest that the immune-stimulating properties of psilocybin mushrooms are unlikely to trigger a cytokine storm.

The immunologist Dr Stephen Wilson confirms that the magic mushroom compounds do not mimic inflammatory cytokines. Instead, they have been shown to enhance the immune system’s ability to identify and respond to specific threats, and the effects of chemical interactions in the body are well within a safe and controlled range.

Challenges and Unanswered Questions

The potential healing and medicinal properties of psilocybin therapy and medicinal mushrooms in addressing various medical conditions, including those arising from the COVID-19 pandemic, holds great promise.  Whilst ongoing trials offer exciting prospects, certain challenges remain. Identifying the specific mushroom or herb components responsible for their effects is a complex task. Ensuring consistency in potency among different batches presents another hurdle.


Additionally, understanding the potential interactions between mushrooms, herbs, and other therapies is vital for comprehensive patient care. This is important to understand in order to harness the healing potential of medicinal mushrooms as a treatment for the symptoms of COVID-19.

The Future of Magic Mushrooms and Post-COVID Psychiatry

Beyond their role in combating COVID-19, magic mushrooms have been researched by psychiatrists for treating mental health conditions including anxiety, PTSD, and depression. Trials involving the safe and efficient use of psilocybin therapy for major depression that is resistant to treatment is underway.

To navigate the challenges posed by the pandemic, the trials have implemented various safety measures including symptom checklists, temperature checks, COVID-19 testing, enhanced hygiene protocols, personal protective equipment, and remote study visits where feasible.


Medical science continues to unravel the mysteries of these remarkable magic mushrooms. Psilocybin mushrooms will play a crucial role in the future of medicinal healing for your physical, mental, emotional, and spiritual well-being. Scientific research is producing more proof and evidence of the healing abilities of magic mushrooms, and someday maybe we will have legally prescribed magic mushroom medicine.



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